Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features
Identifieur interne : 000343 ( Main/Exploration ); précédent : 000342; suivant : 000344Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features
Auteurs : Friederike Fritze [Norvège] ; Uwe Ehrt [Norvège] ; Hogne S Nnesyn [Norvège] ; Martin Kurz [Norvège] ; Tibor Hortobágyi [Royaume-Uni] ; Sabine Piepenstock Nore [Norvège] ; Clive Ballard [Royaume-Uni] ; Dag Aarsland [Norvège]Source :
- International Journal of Geriatric Psychiatry [ 0885-6230 ] ; 2011-10.
English descriptors
Abstract
Background: Depression is common in dementia, with important clinical implications. Few studies of depression in dementia with Lewy bodies are available, and the results are inconsistent. Objective: To examine the frequency of depression and its characteristics and correlates, in people with mild dementia. Methods: All referrals for patients with a first time diagnosis of dementia to geriatric and older psychiatry outpatient clinics in the counties of Rogaland and Hordaland in Western Norway from March 2005 to March 2007 were screened for the study. Participants and their caregivers underwent a comprehensive and standardised diagnostic and assessment procedure. The depression subitem of the neuropsychiatric inventory (NPId) and Montgomery and Åsberg depression rating scale (MADRS) were used to estimate depression. Cut‐off scores for any depression were 0/1 (NPId) and 6/7 (MADRS), and for clinically significant depression 3/4 and 14/15, respectively. Results: Two hundered and twenty‐three subjects with dementia participated, of whom 59 and 50% showed symptoms of depression assessed by NPI or MADRS, respectively, and 25 and 16% had clinically significant depression as measured by NPI and MADRS, respectively. Depression was more frequent in dementia with Lewy bodies (DLB) than in Alzheimer's disease (AD; p < 0.05). APOE genotype was available in 153 patients, and in AD, but not in DLB, a general linear model showed that the presence of APOEε4 allele was significantly associated with depression (F = 4.14; p = 0.045). Conclusion: Depression is common even in mild dementia, and more common and severe in DLB compared to AD. Future studies should explore the longitudinal course of depression in DLB, and the neural underpinnings of depression in DLB. Copyright © 2010 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/gps.2643
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features</title><author><name sortKey="Fritze, Friederike" sort="Fritze, Friederike" uniqKey="Fritze F" first="Friederike" last="Fritze">Friederike Fritze</name></author><author><name sortKey="Ehrt, Uwe" sort="Ehrt, Uwe" uniqKey="Ehrt U" first="Uwe" last="Ehrt">Uwe Ehrt</name></author><author><name sortKey="S Nnesyn, Hogne" sort="S Nnesyn, Hogne" uniqKey="S Nnesyn H" first="Hogne" last="S Nnesyn">Hogne S Nnesyn</name></author><author><name sortKey="Kurz, Martin" sort="Kurz, Martin" uniqKey="Kurz M" first="Martin" last="Kurz">Martin Kurz</name></author><author><name sortKey="Hortobagyi, Tibor" sort="Hortobagyi, Tibor" uniqKey="Hortobagyi T" first="Tibor" last="Hortobágyi">Tibor Hortobágyi</name></author><author><name sortKey="Nore, Sabine Piepenstock" sort="Nore, Sabine Piepenstock" uniqKey="Nore S" first="Sabine Piepenstock" last="Nore">Sabine Piepenstock Nore</name></author><author><name sortKey="Ballard, Clive" sort="Ballard, Clive" uniqKey="Ballard C" first="Clive" last="Ballard">Clive Ballard</name></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:ACD2EF97F29D6586C78ED9317D7C8A65EBA22D6C</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/gps.2643</idno><idno type="url">https://api.istex.fr/document/ACD2EF97F29D6586C78ED9317D7C8A65EBA22D6C/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000E56</idno><idno type="wicri:Area/Main/Curation">000C89</idno><idno type="wicri:Area/Main/Exploration">000343</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features</title><author><name sortKey="Fritze, Friederike" sort="Fritze, Friederike" uniqKey="Fritze F" first="Friederike" last="Fritze">Friederike Fritze</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Ehrt, Uwe" sort="Ehrt, Uwe" uniqKey="Ehrt U" first="Uwe" last="Ehrt">Uwe Ehrt</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="S Nnesyn, Hogne" sort="S Nnesyn, Hogne" uniqKey="S Nnesyn H" first="Hogne" last="S Nnesyn">Hogne S Nnesyn</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Internal Medicine, Section of Geriatrics, Stavanger University Hospital, Hillevåg, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Kurz, Martin" sort="Kurz, Martin" uniqKey="Kurz M" first="Martin" last="Kurz">Martin Kurz</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Clinic for Neurology, Stavanger University Hospital, Hillevåg, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Hortobagyi, Tibor" sort="Hortobagyi, Tibor" uniqKey="Hortobagyi T" first="Tibor" last="Hortobágyi">Tibor Hortobágyi</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neuroscience, Medical Research Council (MRC) Centre for Neurodegeneration Research, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Nore, Sabine Piepenstock" sort="Nore, Sabine Piepenstock" uniqKey="Nore S" first="Sabine Piepenstock" last="Nore">Sabine Piepenstock Nore</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Section for Geriatric Medicine, Haraldsplass Hospital, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Ballard, Clive" sort="Ballard, Clive" uniqKey="Ballard C" first="Clive" last="Ballard">Clive Ballard</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wolfson Centre for Age‐Realted Diseases, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Geriatric Psychiatry</title><title level="j" type="abbrev">Int. J. Geriat. Psychiatry</title><idno type="ISSN">0885-6230</idno><idno type="eISSN">1099-1166</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2011-10">2011-10</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1054">1054</biblScope><biblScope unit="page" to="1061">1061</biblScope></imprint><idno type="ISSN">0885-6230</idno></series><idno type="istex">ACD2EF97F29D6586C78ED9317D7C8A65EBA22D6C</idno><idno type="DOI">10.1002/gps.2643</idno><idno type="ArticleID">GPS2643</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-6230</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer's disease</term><term>dementia</term><term>dementia with Lewy bodies</term><term>depression</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Depression is common in dementia, with important clinical implications. Few studies of depression in dementia with Lewy bodies are available, and the results are inconsistent. Objective: To examine the frequency of depression and its characteristics and correlates, in people with mild dementia. Methods: All referrals for patients with a first time diagnosis of dementia to geriatric and older psychiatry outpatient clinics in the counties of Rogaland and Hordaland in Western Norway from March 2005 to March 2007 were screened for the study. Participants and their caregivers underwent a comprehensive and standardised diagnostic and assessment procedure. The depression subitem of the neuropsychiatric inventory (NPId) and Montgomery and Åsberg depression rating scale (MADRS) were used to estimate depression. Cut‐off scores for any depression were 0/1 (NPId) and 6/7 (MADRS), and for clinically significant depression 3/4 and 14/15, respectively. Results: Two hundered and twenty‐three subjects with dementia participated, of whom 59 and 50% showed symptoms of depression assessed by NPI or MADRS, respectively, and 25 and 16% had clinically significant depression as measured by NPI and MADRS, respectively. Depression was more frequent in dementia with Lewy bodies (DLB) than in Alzheimer's disease (AD; p < 0.05). APOE genotype was available in 153 patients, and in AD, but not in DLB, a general linear model showed that the presence of APOEε4 allele was significantly associated with depression (F = 4.14; p = 0.045). Conclusion: Depression is common even in mild dementia, and more common and severe in DLB compared to AD. Future studies should explore the longitudinal course of depression in DLB, and the neural underpinnings of depression in DLB. Copyright © 2010 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Norvège</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Norvège"><noRegion><name sortKey="Fritze, Friederike" sort="Fritze, Friederike" uniqKey="Fritze F" first="Friederike" last="Fritze">Friederike Fritze</name></noRegion><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><name sortKey="Ehrt, Uwe" sort="Ehrt, Uwe" uniqKey="Ehrt U" first="Uwe" last="Ehrt">Uwe Ehrt</name><name sortKey="Kurz, Martin" sort="Kurz, Martin" uniqKey="Kurz M" first="Martin" last="Kurz">Martin Kurz</name><name sortKey="Nore, Sabine Piepenstock" sort="Nore, Sabine Piepenstock" uniqKey="Nore S" first="Sabine Piepenstock" last="Nore">Sabine Piepenstock Nore</name><name sortKey="S Nnesyn, Hogne" sort="S Nnesyn, Hogne" uniqKey="S Nnesyn H" first="Hogne" last="S Nnesyn">Hogne S Nnesyn</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hortobagyi, Tibor" sort="Hortobagyi, Tibor" uniqKey="Hortobagyi T" first="Tibor" last="Hortobágyi">Tibor Hortobágyi</name></region><name sortKey="Ballard, Clive" sort="Ballard, Clive" uniqKey="Ballard C" first="Clive" last="Ballard">Clive Ballard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000343 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000343 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:ACD2EF97F29D6586C78ED9317D7C8A65EBA22D6C
|texte= Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features
}}
| This area was generated with Dilib version V0.6.23. |  |